The recently published MOVES Investigation Group clinical trials showed treatment with glucosamine and chondroitin was as effective in treating knee osteoarthritis as Celebrex.
Published in the Annals of the Rheumatic Diseases, the study documents 606 patients with moderate-to-severe pain that were treated with the much recommended dietary supplements instead of the COX 2 inhibitor. The study yielded nearly identical results. There was a 50.1% decrease for the vitamins compared with a 50.2% decrease among patients given Celebrex.
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Hochberg, M. C., Martel-Pelletier, J., Monfort, J., Möller, I., Castillo, J. R., Arden, N., . . . on behalf of the MOVES Investigation Group (2015). Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: A multicentre, randomised, double-blind, non-inferiority trial versus celecoxib. Annals of the Rheumatic Diseases, annrheumdis-2014-206792. doi:10.1136/annrheumdis-2014-20679. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/25589511