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exercise genetics

Exercise Reprograms Genetics

Exercise more, live longer?

A recent study compared the health of muscle tissues that endured different activity levels. After 3 months of exercising one leg and not the other, muscle tissue assays of the healthy individuals showed dramatic genetic changes.

There were “significant methylation changes at almost 5000 sites across the genome and significant differential expression of approximately 4000 genes.”

The type of changes observed were the opposite of what was previously thought to occur only over long periods of time with age, or disease.

In other words, exercise may truly be a fountain of youth.


Lindholm, M. E., Marabita, F., Gomez-Cabrero, D., Rundqvist, H., Ekström, T. J., Tegnér, J., & Sundberg, C. J. (2015). An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training. Epigenetics, Taylor & Francis. doi:10.4161/15592294.2014.982445.  Retrieved from


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